Endocrine Abstracts

The angiotensin II type 1 receptor (AT1R) belongs to the family of seven trans-membrane (7TM) receptors, also referred to as G-protein coupled receptors. The AT1R is the primary effector of the renin–angiotensin system, and serves as a key regulator of cardiovascular physiology. The importance of the receptor is clearly illustrated be the frequent use of AT1R blockers and ACE inhibitors in cardiovascular medicine. Upon binding of Ang II th...